Phenylpropanoids constituents of Pedicularis dichotoma
10.7501/j.issn.0253-2670.2014.09.005
- Author:
Hong-Biao CHU
1
Author Information
1. Medical School, Jinggangshan University
- Publication Type:Journal Article
- Keywords:
Anti-fatigue;
Leucoseptoside A;
Pedicularis dichotoma Bonati;
Pedicularis Linn.;
Phenylpropanoids;
Salidroside;
Verbascoside;
Zizybeoside I
- From:
Chinese Traditional and Herbal Drugs
2014;45(9):1223-1227
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the phenylpropanoid constituents from the whole plants of Pedicularis dichotoma and the anti-fatigue activities in vivo. Methods: The n-BuOH fraction of 95% ethanol extract from P. dichotoma was separated and purified by silica gel, re-phase and Sephadex LH-20 column chromatography. The structures of the compounds were identified by physicochemical properties and various spectroscopic methods. The compounds were tested on anti-fatigue activity using mice in swimming model. Results: Twelve phenylpropanoid compounds were isolated and purified. Their structures were identified as verbascoside (1), isoverbascoside (2), leucoseptoside A (3), jionoside D (4), martynoside (5), isomartynoside (6), cis-martynoside (7), citrusin C (8), robustaside B (9), darendoside B (10), zizybeoside I (11), and salidroside (12). Verbascoside could obviously prolong the swimming time of mice. Conclusion: Compounds 1-12 are obtained from the plant for the first time, and compound 11 is reported from the plants of Pedicularis Linn. for the first time. Phenylpropanoids show obvious anti-fatigue activities.
