Antiviral effect of Reduning Injection against coxsackievirus A16
10.7501/j.issn.0253-2670.2014.10.018
- Author:
Ze-Yu CAO
1
Author Information
1. Jiangsu Kanion Parmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Antivirus;
Coxsackievirus A16;
Hand-foot-mouth disease;
Reduning Injection;
Vero cells
- From:
Chinese Traditional and Herbal Drugs
2014;45(10):1450-1455
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To verify the antiviral effects of Reduning Injection against coxsackievirus A16 (CoxA16) in vivo and in vitro. Methods: Vero cells and 5-day-old suckling mice, injected with 75/50 and 106 TCID50 CoxA16, were used as evaluation models. The preventive influences of Reduning Injection against CoxA16 in Vero cells were assessed in the models. The effects of Reduning Injection on the mortality, survival time, change rate of body weight, and clinical symptom scores of suckling mice were observed. Results: In Vero cells, cytopathic effects induced by 75 and 50 TCID50 CoxA16 were obviously relieved by crude drug5.0 mg/mL Reduing Injection respectively. Meanwhile, mice death caused by CoxA16 was markedly rescued, survival time was prolonged, and growth inhibition was recovered by Reduing Injection. Meanwhile, the clinical symptom induced by virus was also improved. Conclusion: The endogenous and exogenous antivirus effects of Reduning Injection on CoxA16 are proven.
