Study on alkaloids from Corydalis saxicola and their anti-oxidative activities
10.7501/j.issn.0253-2670.2014.11.005
- Author:
Zhi-Chao HE
1
Author Information
1. Department of Pharmacy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Anti-oxidative activities;
Canadine;
Cheilanthifoline;
Corydalis saxicola Bunting;
Pallidine
- From:
Chinese Traditional and Herbal Drugs
2014;45(11):1526-1531
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the alkaloids from Corydalis saxicola and their anti-oxidative activities. Methods: The alkaloids were separated and purified by various column chromatography and identified according to their spectral analyses. The anti-oxidation activities were investigated on DPPH radical scavenging assay. Results: Sixteen compounds were obtained and identified as cavidine (1), stylopine (2), canadine (3), tetrahydropalmatine (4), cheilanthifoline (5), scoulerine (6), protopine (7), dehydrocheilanthifoline (8), dehydroisoapocavidine (9), berberine (10), dehydrodiscretamine (11), chelerythrine (12), dehydrocavidine (13), corypalline (14), isocorydine (15), and pallidine (16). The alkaloids from C. saxicla were measured by the model of scavenging the stable DPPH radical, which showed a concentration dependent scavenging effect. Conclusion: Compounds 3, 5, 8, 11, and 16 are isolated from C. saxicola for the first time. Compounds 5 and 16 show the strong anti-oxidative activities.
