Preparation technology for orally disintegrating tablets of fresh antler with all ingredients
10.7501/j.issn.0253-2670.2014.12.010
- Author:
Bao-Xia WEI
1
Author Information
1. Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Fresh antler;
Homogenate;
Lyophilized;
Orally disintegrating tablets;
Preparation technology
- From:
Chinese Traditional and Herbal Drugs
2014;45(12):1709-1713
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the critical influence factors in the preparation of orally disintegrating tablets of fresh antler with all ingredients (ODT-FA) by lyophilized method and to optimize the preparation technology. Methods: The lyophilized molding technology was used to prepare the ODT-FA and the optimal formulation and preparation were obtained by means of single factor test with promoting cell proliferation activity, moisture content, disintegration time, and appearance as evaluation criterion. Results: The optimal preparation conditions of ODT-FA were as follows: The frozen storage temperature of fresh antler was -40°C, acetate buffer was used as diluent to mix with the fresh antler powder according to ratio of 1:2, then to homogenize for 10 min under liquid nitrogen protection with 10% trehalose as lyoprotectant, and the homogenate was lyophilized in vacuum after poured into the mold to prepare the ODT-FA. The tablets could disintegrate within 30 s completely and its moisture content was less than 5%. In addition, there was no difference in promoting cell proliferation compared with fresh antler. Conclusion: The ODT-FA prepared by optimal technology has highly biological activity and is easy to take. The optimal preparation process is stable and suitable for industrial production.
