A Case of Osteomalacia with Long Term Carbamazepine Therapy.
- Author:
Hee Soo KIM
1
;
Dong Sun KIM
;
Nak Won CHOI
;
Sang Hyun BAIK
;
Sung Hoon KIM
;
Chang Beom LEE
;
Yong Soo PARK
;
Woong Hwan CHOI
;
You Hern AHN
;
Tae Hwa KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Osteomalacia;
Anticonvulsant;
Carbamazepine;
Sunlight exposure
- MeSH:
Anticonvulsants;
Carbamazepine*;
Humans;
Male;
Metabolism;
Motor Activity;
Osteomalacia*;
Phenobarbital;
Phenytoin;
Primidone;
Sunlight;
Vitamin D;
Young Adult
- From:Journal of Korean Society of Endocrinology
2000;15(2):286-290
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anticonvusant therapy with any of several agents, especially phenytoin, phenobarbital, and primidone causes disturbances in bone mineral metabolism. Anticonvulsants stimulate the hepatic microsomal mixed-oxidase enzymes and hence increase the rate of clearance of vitamin D and its metabolism. The severity of clinical manifestations in any given individual appears to be a function of the combined effects of variety of factors including drug type and total drug dose, dietary vitamin D intake, sunlight exposure, and physical activity level. We report a case of osteomalacia associated with long term carbamazepine therapy in a 21-year-old male with less exposure to sunlight.
