Analysis on theory and technology method of multicomponent drug metabolism
10.7501/j.issn.0253-2670.2014.12.001
- Author:
Yang LIU
1
Author Information
1. Beijing University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Concurrent metabolism;
Multicomponent drug metabolism;
Multiple metabolism;
Sequential metabolism;
Technology method;
Theory system
- From:
Chinese Traditional and Herbal Drugs
2014;45(12):1663-1667
- CountryChina
- Language:Chinese
-
Abstract:
The core of multicomponent drug metabolism is the mutual influence of the transporters and drug metabolic enzymes interaction of more ingredients, with the simultaneous determination for multiple components as the principle, and with many components changes on the environmental impact as the emphasis. Its theoretical content composes by sequential metabolism, concurrent metabolism, and multiple metabolism. On the principles of multicomponent simultaneous determination, metabolic continuous time records, metabolic continuous space records, and the combination of qualitative and quantitative research, the multicomponent drug metabolism is researched by the experimental methods of in vivo, in situ, and in vitro. In visual mode of the comparative analysis with the quantitative data evaluation, multicomponent drug metabolism can be thought of emerging research direction with solid academic foundation and advanced technical means.
