Chemical constituents from Guanxinning Injection
10.7501/j.issn.0253-2670.2014.13.006
- Author:
Ming RUAN
1
Author Information
1. School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University
- Publication Type:Journal Article
- Keywords:
Ferulic acid;
Guanxinning Injection;
Ligusticum chuanxiong Hort.;
Protocatechuic aldehyde;
Salvia miltiorrhiza Bge.;
Senkyunolide I
- From:
Chinese Traditional and Herbal Drugs
2014;45(13):1838-1844
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents from Guanxinning Injection. Methods: The chemical constituents were repeatedly isolated by column chromatographic techniques including silica gel, ODS, Sephadex LH-20, and macroporous resin, and were purified by preparation HPLC chromatography and recrystallization, and their structures were identified by physicochemical properties and spectroscopic data. Results: Nineteen compounds were isolated and identified as protocatechuic aldehyde (1), vanillin (2), ferulic acid (3), 2-furoic acid (4), senkyunolide I (5), caffeic acid (6), salvianolic acid A (7), isosalvianolic acid A (8), salvianolic acid B (9), isosalvianolic acid C (10), rosmarinic acid (11), 1, 3-dicaffeoylquinic acid (12), senkyunolide H (13), 4-hydroxybenzoic acid (14), m-hydroxybenzoic acid (15), o-hydroxybenzoic acid (16), 4-hydroxycinnamic acid (17), methyl rosmarinate (18), and salvianolic acid N methyl ester (19). Conclusion: Nineteen compounds are isolated from the Guanxinning Injection for the first time, and all HPLC analyses and literature data show that compounds 2, 3, 5, 13-16 are originated from Ligusticum chuanxiong, compounds 7-11, and 18-19 from Salvia miltiorrhiza, and compounds 1, 4, 6, 12, and 17 from L. chuanxiong and S. miltiorrhiza.
