New natural product from lipophilic parts in roots of Angelica dahurica
10.7501/j.issn.0253-2670.2014.13.003
- Author:
Ai-Hong ZHAO
1
Author Information
1. Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University
- Publication Type:Journal Article
- Keywords:
Angelol A;
Dahurianol;
Heraclenol;
Isoimperatorin;
Lipophilic chemical constituent;
Psoralen;
Roots of Angelica dahurica Benth. et Hook. f. ex Franch. et Sav.;
Vanillic acid;
Xanthotoxin
- From:
Chinese Traditional and Herbal Drugs
2014;45(13):1820-1828
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of lipophilic parts from the roots of Angelica dahurica. Methods: The compounds were separated and purified by repeated column chromatography on silica gel and HPLC, as well as the chemical structures of isolated compounds were determined by spectral data analyses. Results: Forty compounds were obtained and identified as isoimperatorin (1), psoralen (2), bergapten (3), β-sitosterol (4), imperatorin (5), phellopterin (6), xanthotoxin (7), isopimpinellin (8), dehydrogeijerin (9), isooxypeucedanin (10), oxypeucedanin (11), dibutylphthalate (12), umbelliferone (13), xanthotoxol (14), 5-hydroxy-8-methoxypsoralen (15), p-hydroxyphenethyl-trans-ferulate (16), pabularinone (17), isobyakangelicol (18), heraclenin (19), columbianetin (20), isogosferol (21), pabulenol (22), byakangelicin ethoxide (23), neobyakangelicol (24), oxypeucedanin methanolate (25), isoscopletin (26), 1′, 2′-dehydromarmesin (27), angelol A (28), angelol E (29), tert-O-methylheraclenol (30), (-)-marmesin (31), dahurianol {8-[(2′R)-2′, 3′-dihydroxy-3′-methylbutoxy] bergaptol; 32}, oxypeucedanin hydrate (33), heraclenol (34), byakangelicin (35), angelol L (36), angelol G (37), trans-coniferylaldehyde (38), vanillic acid (39), and trans-ferulic acid (40), respectively. Conclusion: Compound 32 is a new natural product named dahurianol.
