Application of transcriptomic technologies in hepatotoxicity induced by Chinese materia medica
10.7501/j.issn.0253-2670.2015.10.024
- Author:
Li-Hua XIE
1
Author Information
1. Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Biomarkers;
Gene chip;
Hepatotoxicity induced by Chinese materia medica;
RT-PCR;
Transcriptomics
- From:
Chinese Traditional and Herbal Drugs
2015;46(10):1536-1541
- CountryChina
- Language:Chinese
-
Abstract:
As a science of cell genetic transcription and transcriptional regulation at the unitary level, transcriptomics has been applied in basic medicine, biology, microbiology, pharmacy, and so on. In the study on Chinese materia medica (CMM), transcriptomics is used to evaluate the efficacy and toxicity by comparing the changes of gene expression profile before and after drug treatment. To provide the valuable references for the research the development of transcriptomic technology, this article reviewed the progress of its application in CMM research, especially in biomarker screening and mechanism elucidating on the hepatotoxicity induced by CMM.
