Advances in study on baicalein for regulation of signaling pathways in myocardial ischemia/hypoxia
10.7501/j.issn.0253-2670.2015.11.024
- Author:
Xiao-Yan HE
1
Author Information
1. College of Pharmaceutical Sciences, Southwest University
- Publication Type:Journal Article
- Keywords:
Apoptosis proteins;
Baicalein;
Cardioprotection;
Ischemia/hypoxia;
Signaling pathways
- From:
Chinese Traditional and Herbal Drugs
2015;46(11):1685-1691
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia/hypoxia often results in damaging the structure and function of heart. Baicalein, a widely distributed flavonoid, has been shown to play an important role in the cardioprotection of ischemia/hypoxia in recent years. The cardioprotection of baicalein was mediated by regulating the cell signaling pathways and controlling the phosphorylation of key signaling molecules. These signaling pathways involved in phosphatidylinositol-3-kinase-serine/threonine kinase (PI3K/Akt), mitogen-activated protein kinase (MAPKs), and nuclear factor-κB (NF-κB), and their down signaling proteins HMGB1, MMP-2/-9, and eNOS, and apoptosis proteins as well. The interaction mechanism of baicalein on signaling pathway in myocardial ischemia/hypoxia has been reviewed.
