Optimization of rutaecarpine solid lipid nanoparticles by central composite design and response surface methodology
10.7501/j.issn.0253-2670.2015.09.010
- Author:
Chun-Lin YAN
1
Author Information
1. Basic Medical College, Hebei North University
- Publication Type:Journal Article
- Keywords:
Average particle size;
Central composite design;
Entrapment efficiency;
Film-ultrasound method;
Response surface methodology;
Rutaecarpine;
Solid lipid nanoparticles;
Zeta potential
- From:
Chinese Traditional and Herbal Drugs
2015;46(9):1307-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the prescription of rutaecarpine solid lipid nanoparticles (Rut-SLN). Methods: Using the film-ultrasound method to lining-up the Rut-SLN, with the entrapment efficiency (EE), Zeta potential, and the average particle size as the evaluation indexes, using central composite design to inspect the effects of glycerol monostearate/drug quality ratio (A), soybean lecithin for injection/glycerol monostearate mass ratio (B), Poloxamer 188 (C) on three factors of the EE, Zeta potential, and average particle size. Prediction and analysis for selecting the best prescription condition were carried out by using the response surface method. Results: According to the optimized prescription, the EE, Zeta potential, and the average particle size of Rut-SLN was respectively 84.27%, 122.6 nm, and -20.7 mV. Conclusion: The optimal prescription of Rut-SLN has better stability, feasibility, and high EE, which is suitable for the production.
