Study on molecular mechanism of Paeoniae Rubra Radix and Phellodendri Cortex intervening Alzheimer's disease using network pharmacology methods
10.7501/j.issn.0253-2670.2015.11.013
- Author:
Xiao-Qian TAO
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Molecular docking;
Network pharmacology;
Paeoniae Rubra Radix;
Phellodendri Cortex
- From:
Chinese Traditional and Herbal Drugs
2015;46(11):1634-1639
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To conduct computing network pharmacological studies on Paeoniae Rubra Radix (Chishao) and Phellodendri Cortex (Huangbai), and to explore their mechanism for intervening Alzheimer's disease (AD). Methods: The interactions among 199 compounds from the two kinds of Chinese Herbs (Chishao and Huangbai) and 23 approved drug targets related to AD were studied with molecular docking and network pharmacological analysis methods. Results: The most of the compounds in Chishao and Huangbai exhibit good drug-like properties. The mechanism of Chishao and Huangbai may be that they modulate the expression of GSK-3β, caspase-7, BchE, and mTOR to resist AD. Conclusion: The method of network pharmacological studies is helpful to explore the possible active molecules in Chishao and Huangbai and elucidate the mechanism of action.
