Research on preparation of arctigenin from Arctii Fructus
10.7501/j.issn.0253-2670.2015.11.010
- Author:
Yong-Xia GUAN
1
Author Information
1. Lunan Pharmaceutical Group Co., Ltd., State Key Laboratory, Generic Manufacture Technology of Chinese Traditional Medicine
- Publication Type:Journal Article
- Keywords:
Acid hydrolysis;
Arctigenin;
Arctiin;
Crystallization;
Industrialization
- From:
Chinese Traditional and Herbal Drugs
2015;46(11):1620-1624
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the difficult extraction technology of Arctii Fructus in separation of arctigenin industrialization, which provides a practical preparation technology suitable for arctigenin industrialization in order to promote the industrialization development of arctigenin. Methods: Arctii Fructus was hydrolyzed by acid hydrolysis and alcohol extraction. Then the crude product was separated by ethyl acetate extraction. Finally the pure product of arctigenin was obtained through ethanol crystallization. Results: We obtained the crude product which the purity was more than 75.0% by simple extraction and separation. The finished product was crystallized with anhydrous ethanol until the purity of arctigenin is more than 99.0%. Conclusion: This study obtains a suitable process for arctigenin industrialization preparation.
