Study on chemical constituents from Re-Du-Ning Injection (II)
10.7501/j.issn.0253-2670.2015.11.006
- Author:
Hai-Bo LI
1
Author Information
1. Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
5-O-caffeoylquinic acid;
Antivirus;
Caffeoylquinic acid;
Re-Du-Ning Injection;
Secologanic acid
- From:
Chinese Traditional and Herbal Drugs
2015;46(11):1597-1602
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents from Re-Du-Ning Injection (RDN). Methods: The chemical constituents were isolated by chromatography on silica gel, ODS, Sephadex LH-20, and Toyopearl HW-40 columns and reverse phase MPLC and HPLC repeatedly. Their structures were identified by spectral data and physicochemical property. Results: Sixteen compounds were isolated and identified as 5-O-caffeoylquinic acid (1), 5-O-caffeoylquinic acid methyl ester (2), 4-O-caffeoylquinic acid (3), 5-O-caffeoylquinic acid methyl ester (4), 4,5-di-O-caffeoylquinic acid (5), 4,5-di-O-caffeoylquinic acid methyl ester (6), 3,5- di-O-caffeoylquinic acid (7), 3,5-di-O-caffeoylquinic acid methyl ester (8), 3,4-di-O-caffeoylquinic acid (9), 3,4-di-O-caffeoylquinic acid methyl ester (10), secologanic acid (11), vogeloside (12), 7-epi-vogeloside (13), E-aldosecologanin (14), Z-aldosecologanin (15), and 5H,8H-pyrano[4,3-d] thiazolo[3,2-a] pyridine-3-carboxylic acid (16). Compounds 1-10 showed high efficiency and low toxicity with antivirus activity against RSV. Conclusion: All the isolated compounds are reported from RDN Injection for the first time, and caffeoylquinic acids may be one of antivirus pharmacodynamic material bases of RDN.
