Two new triterpenoid saponins from roots and rhizomes of Glycyrrhiza uralensis
10.7501/j.issn.0253-2670.2015.11.002
- Author:
Jing LENG
1
Author Information
1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University
- Publication Type:Journal Article
- Keywords:
22β-acetyl-uralsaponin C;
Liquiritin;
Macedonoside E;
Naringenin;
Ononin;
Roots and rhizomes of Glycyrrhiza uralensis
- From:
Chinese Traditional and Herbal Drugs
2015;46(11):1576-1582
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the roots and rhizomes of Glycyrrhiza uralensis. Methods: The roots and rhizome of G. uralensis were extracted with 95% EtOH. Then the extract was partitioned with petroleum ether, ethyl acetate, and n-butanol successively. The n-butanol fraction was isolated by silica gel and ODS column chromatography and preparative HPLC. The structures of compounds were identified by spectroscopic methods (UV, MS, 1D-NMR, and 2D-NMR). Results: Fourteen compounds were obtained from the n-butanol fraction. They were macedonoside E (1), 22β-acetyl-uralsaponin C (2), glycyrrhizic acid (3), uralsaponin F (4), licorice-saponin G2 (5), 22β-acetoxyl-glycyrrhaldehyde (6), 3β-O-[β-D-(6-methyl)-glucuronopyranosyl-(1→2)-β-D-glucuronopyranosyl]-glycyrrhizic acid (7), liquiritigenin (8), naringenin (9), isoliquiritigenin (10), ononin (11), liquiritin (12), isoviolanthin (13), and liquiritin apioside (14). Conclusion: Macedonoside E (1) and 22β-acetyl-uralsaponin C (2) are new compounds.
