Optimization of preparation technology for total glucosides from Paeonia lactiflora liposome by BBD-RSM and its in vitro release
10.7501/j.issn.0253-2670.2015.03.010
- Author:
Dan ZHANG
1
Author Information
1. Department of Pharmacy, Luzhou Medical College
- Publication Type:Journal Article
- Keywords:
Box-Behnken design-response surface method;
In vitro release;
Liposome;
Sustained release;
Total glucosides from Paeonia lactiflora
- From:
Chinese Traditional and Herbal Drugs
2015;46(3):359-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation technology for total glucosides from Paeonia lactiflora (TGP) liposome and study on its in vitro release. Methods: Liposomes were prepared by reverse-phase evaporation technique. Taking the entrapment efficiency (EE) as indexes, the preparation of liposome was optimized using Box-Behnken design-response surface method (BBD-RSM), and the in vitro release was studied. Results: The optimal formulation was cholesterol-lecithin (1:2.7), TGP-lipid (1:29), and hydrated medium of 5.1 mL. The average EE were 73.0% and the 12 h in vitro accumulative release rate was 42.18%. Conclusion: The optimized process is rational and feasible, and the TGP liposome has the higher EE and good stability with better sustained release in vitro.
