UPLC-Q-TOF-MS analysis on constituents of Tianshu Capsule absorbed into plasma
10.7501/j.issn.0253-2670.2015.05.007
- Author:
Jian-Ping QIN
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
5-hydroxymethy furfural;
Caffeic acid;
Constituents absorbed into plasma;
Ferulic acid;
Gastrodin;
Ligustilide;
Ligustrazine hydrochloride;
Tianshu Capsule;
UPLC-Q-TOF-MS
- From:
Chinese Traditional and Herbal Drugs
2015;46(5):649-653
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents of Tianshu Capsule in vivo and in vitro. UPLC-Q-TOF-MS was used as the analytic method. The ferulic acid, caffeic acid, ligustrazine hydrochloride, gastrodin, 5-hydroxymethy furfural, and ligustilide were used as the reference compounds. The information on the total ion chromatogram, extraction chromatogram and the mass spectrogram were synthetically analyzed to confirm the constituents of Tianshu Capsule in vivo and in vitro. Twenty-four compounds from Tianshu Capsule were detected among five constituents came from Tianma and 19 constituents came from Chuanxiong. After oral administration of Tianshu Capsule, 13 compounds were absorbed into plasma. The findings obtained from the study can provide the useful information for the determination of bioactive substances and the perfection of quality standard of Tianshu Capsule.
