Sesquiterpenoids from branches and leaves of Cephalotaxus lanceolata
10.7501/j.issn.0253-2670.2015.03.002
- Author:
Ren-Tao ZENG
1
Author Information
1. School of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Cephalotaxus lanceolata K. M. Feng;
Clovandiol;
Lanceoloside A;
Lanceoloside B;
Lanceoloside C;
Loliolide;
Sesquiterpenoids
- From:
Chinese Traditional and Herbal Drugs
2015;46(3):320-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To isolate and identify the chemical constituents from the branches and leaves of Cephalotaxus lanceolata. Methods: The compounds were separated and purified by column chromatography with silica gel, Sephadex LH-20, MPLC, and HPLC. Their structures were elucidated on the basis of spectroscopic methods. Results: Eleven sesquiterpenoids were isolated from 95% ethanol extract of the branches and leaves of C. lanceolata and identified as lanceoloside A (1), lanceoloside B (2), lanceoloside C (3), 9-hydroxy-4,7-megastigmadien-3-one (4), corchoionol C (5), 9,10-dihydroxy-4,7-megastigmadien-3-one (6), 5,12-epoxy-9- hydroxy-7-megastigmen-3-one (7), 5,12-epoxy-6,9-hydroxy-7-megastigmen-3-one (8), loliolide (9), (3S,5R,8S)-5,8-epoxy-6- megastigmadien-3,9-diol (10), and clovandiol (11) respectively. Conclusion: Compounds 1 is identified as a new sesquiterpenoid, while compounds 2-3 are two new natural products. Compounds 4-11 are isolated from this plant for the first time.
