Advances in study on biosynthsis of O-glucuronides
10.7501/j.issn.0253-2670.2015.07.023
- Author:
Mei-Ling WANG
1
Author Information
1. Department of Biotechnology, Dalian Medical University
- Publication Type:Journal Article
- Keywords:
Animal UGT;
Microbial fermentation;
O-glucuronides;
Plant biosynthesis;
UDP-glucuronosylatransferase
- From:
Chinese Traditional and Herbal Drugs
2015;46(7):1065-1073
- CountryChina
- Language:Chinese
-
Abstract:
Glucuronidation is one of the most important metabolic reactions in vivo, while O-glucuronidation is the major reaction type. The synthesis of O-glucuronides is very helpful for the further studies on the evaluation of biological activity and safety of O-glucuronids, as well as drug metabolism and pharmacokinetic studies. The enzymatic catalysis process using UDP-glucuronosyltransferases (UGTs) is the major method for O-glucuronides biosynthesis. This review summarized the recent progress in enzymatic preparation of O-glucuronides by using different enzyme sources including plants, microorganisms, animals, and recombinant human UGTs. Furthermore, this review also summarized several new techniques to improve the efficacy for biosynthesis of O-glucuronides.
