A new monoterpenoid indole alkaloid from Winchia calophylla
10.7501/j.issn.0253-2670.2015.05.003
- Author:
Ting ZENG
1
Author Information
1. Research Center, Chengdu Medical College
- Publication Type:Journal Article
- Keywords:
Apocynaceae;
Calophyline B;
Monoterpenoid indole alkaloid;
Single-crystal X-ray crystallographic analysis;
Winchia calophylla A. DC.
- From:
Chinese Traditional and Herbal Drugs
2015;46(5):629-632
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the alkaloid constituents from the trunk barks of Winchia calophylla. The constituents were isolated and purified by column chromatography over silica gel and Sephadex LH-20 columns. The structure of the isolated compound was elucidated by MS and NMR spectra, and then confirmed by a single-crystal X-ray crystallographic analysis. The isolated compound was also evaluated for its in vitro cytotoxicity against the proliferation of seven kinds of human cancer cell lines (lung cancer: A549, breast cancer: MCF-7, prostate cancer: PC-3, glioma: U87MG, multiple myeloma: U266, MM1. S, and MM1. R). A new monoterpenoid indole alkaloid, identified as calophyline B (1), was isolated from the ethanol extract of the trunk barks of W. calophylla. Compound 1 is a new compound, which shows no cytotoxicity against the proliferation of the above human tumor cells.
