Application analysis on theory of “correlation in quality, curative effect, and metabolism” in quality control of genuine medicinal materials
10.7501/j.issn.0253-2670.2015.02.001
- Author:
Jing-Juan WANG
1
Author Information
1. Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Genuine medicinal materials;
Model for quality evaluation;
Multi-component drug analysis;
Quality control;
“Correlation in quality, curative effect, and metabolism”
- From:
Chinese Traditional and Herbal Drugs
2015;46(2):157-162
- CountryChina
- Language:Chinese
-
Abstract:
Genuine medicinal materials (GMM) is the representative of high quality materials, the particular area, excellent quality, and good efficacy make it into the essence of traditional Chinese medicine (TCM). But the scientific connotation of the GMM quality and the relationship between the quality and efficacy of GMM are the emphases and difficulty in its study. The evaluation on the theory system of “correlation in quality, curative effect, and metabolism” is carried on the curative effect with GMMs and non-GMMs as research objects and the simultaneous detection of multi-components as means. The “correlation in quality, efficacy, and metabolism” is based on the combination of chemical analysis method, pharmacological model experiment, and mathematical analysis model calculation method. The quality evaluation indexes and methods of GMM are disscused and the quality of GMM is assessed by the various views of absorption, metabolism, and effectiveness of TCM. At first, the fingerprint method to identify and select the quality control components of GMM is adopted and the qualitative and quantitative methods of multi-components in GMM are established in this study. Then the “correlation of quality, curative effect, and metabolism” is experimented through the comparison on physiological animals and model animals, the constituents are comprehensively investigated. Finally, based on the mathematical models for the medicines-related methods, we can get the components with preferred quality control, which associates with the efficacy and the proportional relationship, ascertain the material basis for the efficacy of GMM, establish a scientific optimal quality evaluation system, and provide the new ideas for the research of GMM.
