Effects of protocatechuic acid on expression of D2DR, iNOS, and TH in striatum and midbrain of Parkinson's disease model mice
10.7501/j.issn.0253-2670.2015.06.015
- Author:
Xue YIN
1
Author Information
1. Binzhou Medical University
- Publication Type:Journal Article
- Keywords:
Dopamine D2 receptor;
Inducible nitric oxide synthase;
MPTP;
Parkinson's disease;
Protocatechuic acid;
Tyrosine hydroxylase
- From:
Chinese Traditional and Herbal Drugs
2015;46(6):866-870
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this paper is to investigate the effects of protocatechuic acid (PCA) on the expression of D2DR, iNOS, and TH in striatum and midbrain of Parkinson's disease (PD) mice induced by MPTP. C57BL brown mice were used as experimental animals and were injected with MPTP (25 mg/kg. d) for 7 d to build PD model mice. PCA (10 mg/kg. d) and Madopar (125 mg/kg. d) had been ip administered to the PD mice for the precaution and treatment at the first and lasted for 7 d. The expression of D2DR, iNOS, and TH in the striatum and midbrain of PD mice induced by MPTP was detected by Western blotting method. The results showed that iNOS expression increased while D2DR and TH expression decreased in the striatum and midbrain of MPTP-induced PD mice. However, PCA significantly decreased the expression of iNOS while obviously increased the expression of D2DR and TH in the striatum and midbrain of MPTP-induced PD mice. PCA has a neuroprotective effect on the PD mice induced by MPTP, and its protective effects on mice brain are achieved at least partly by increasing TH and D2DR expression while decreasing iNOS expression.
