Inhibitory effects of curcumin on hyphal development and biofilm formation of five kinds of non-Candida albicans
10.7501/j.issn.0253-2670.2015.04.016
- Author:
Meng-Xiang ZHANG
1
Author Information
1. School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Biofilms;
Candida glabrata;
Candida guilliermondii;
Candida krusei;
Candida parapsilokis;
Candida tropicalis;
Curcumin;
Hyphae;
Non-Candida albicans
- From:
Chinese Traditional and Herbal Drugs
2015;46(4):549-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the inhibitory effects of curcumin on hyphal development and biofilm formation of five kinds of non-Candida albicans. Methods: Serial 2-fold dilution assay was used to determine the MICs of curcumin to C. tropicalis, C. glabrata, C. parapsilokis, C. krusei, C. guilliermondii; XTT assay was used to determine the SMIC50 of curcumin to the five non-C. albicans. Inverted microscope and scanning electron microscope (SEM) were applied to inspectting the morphological change of non-C. albicans treated by curcumin, The dilution method was applied to inspecting the hyphae around the colonies. Results: The MICs of curcumin to C. tropicalis, C. glabrata, C. parapsilokis, C. Krusei, C. guilliermondii were 64, 128, 256, 256, and 128 μg/mL, and the SMIC50 were 512, 512, >512, >512, and 512 μg/mL, respectively. We found that curcumin could inhibit the hyphal and biofilm formation of the five kinds of non-C. albicans by observation with inverted microscope and SEM, and curcumin could inhibit the hyphal development around the colonies by observation with optical microscope. Conclusion: Curcumin could inhibit the hyphal development and biofilm formation of the five kinds of non-C. albicans.
