Optimization of inclusion process of mixed volatile oil of forsythia oil and peppermint oil by colloid mill method
10.7501/j.issn.0253-2670.2015.04.011
- Author:
Hui-Juan MI
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co. Ltd.
- Publication Type:Journal Article
- Keywords:
Colloid mill;
Inclusion process;
Mixed volatile oil of forsythia oil and peppermint oil;
Response surface optimization
- From:
Chinese Traditional and Herbal Drugs
2015;46(4):520-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation of β-cyclodextrin (β-CD) inclusion compound of forsythia oil and peppermint oil using the colloid mill method. Methods: With recovery ratio and inclusion rate of volatile oil-β-CD as evaluation indexes, the single factor test combining Box-Behnken response surface methodology was used to study the effects of β-CD-pure water ratio, β-CD-volatile oil ratio, and inclusion time on the inclusion process of volatile oil. Using TLC, IR spectrum, and microscopic image, the inclusion complexes were confirmed. Results: The optimum preparation conditions of inclusion compound were as follows: β-CD-pure water ratio was 1:3, mixture of forsythia oil and peppermint oil-β-CD ratio was 1:9, and the inclusion time was 25 min. The formation of inclusion complex was preliminary proved by TLC, IR spectrum, and microscopic image. Conclusion: The method is reasonable and feasible.
