Pharmacodynamics study on in vivo anti-oxidant action of Buyang Huanwu Decoction in mice
10.7501/j.issn.0253-2670.2015.01.019
- Author:
Ji-Ye ZHANG
1
Author Information
1. School of Pharmacy, Health Science Center, Xi'an Jiaotong University
- Publication Type:Journal Article
- Keywords:
Anti-oxidantion;
Buyang Huanwu Decoction;
MDA;
Pharmacodynamics;
Serum pharmacology;
SOD
- From:
Chinese Traditional and Herbal Drugs
2015;46(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the in vivo pharmacodynamics characteristics of Buyang Huanwu Decoction (BHD) in mice, and to provide reference for rational clinical drug use. Methods: The level of MDA and activity of SOD in liver tissue of mice were determined after ig treatment with BHD or its drug-containing serum. Further more, the time-effect and dose-effect relationship of BHD on MDA level and SOD activity were carried out. The parameters of pharmacodynamics were estimated based on the time-effect and dose-effect curves. Results: Compared with control group, both BHD and its drug-containing serum could reduce MDAlevel, while raise SOD activity in the liver of mice (P < 0.05). Time-effect curves both present multi-peak but most pharmacodynamics parameters showed significant differences (P < 0.05), except tp and t1/2(Ka). Conclusion: BHD has obvious antioxidant effect and pharmacodynamics characteristics can be described as one-compartment model.
