Preparation of hyperoside solid nanocrystal and evaluation of its in vitro release
10.7501/j.issn.0253-2670.2015.12.009
- Author:
Na WU
1
Author Information
1. Jiangxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Freeze-drying;
Hyperoside;
In vitro release;
Solid nanocrystal;
Tert-butyl alcohol
- From:
Chinese Traditional and Herbal Drugs
2015;46(12):1759-1763
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare the hyperoside solid nanocrystal (Hyp-SN) and to determine the in vitro release. Methods: The high pressure homogenization technology was applied to preparing Hyp nanosuspension, and then Hyp-NS was solidificated into Hyp-SN by freeze-drying. The fomulation and process of Hyp-SN were optimized by the single factor experiment. Dried powders were prepared under the optimal condition and characterized for crystallinity and particle size. In vitro dissolution of Hyp-SN was also determined. Results: The particle size of Hyp-SN protected by tert-butyl alcohol was (405.2 ± 14.6) nm, as well as the polydispersity index (PI) was 0.25 ± 0.08. The results of SEM showed that Hyp-SN powder was irregular rod and XRD showed Hyp was crystalline in both coarse powder and nanosuspensions. In the in vitro dissolution test, Hyp-SN showed an increased dissolution markedly. Conclusion: The method employed to prepare the Hyp-SN is simple and feasible. Hyp-SN could significantly improve the dissolution of Hyp. It has a broad application prospects.
