Optimization for vacuum belt drying process of Shiwei Penan Granule by using response surface methodology
10.7501/j.issn.0253-2670.2015.13.010
- Author:
Chang-Long LIU
1
Author Information
1. Jiangsu Kanion Parmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Paeoniflorin;
Polydatin;
Response surface methodology;
Shiwei Penan Granule;
Vacuum belt drying
- From:
Chinese Traditional and Herbal Drugs
2015;46(13):1914-1919
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the vacuum belt drying process of Shiwei Penan Granules. Methods: On the base of single factor experiments, feeding rate, heating temperature, and drying time were selected as the main factors, with composite score of moisture content of dry paste, rates of polydatin and paeoniflorin transfer as the response values, response surface methodology was used to optimize the vacuum belt drying process. Results: Optimal parameters were as follows: The feeding rate was 1.6 kg/h, heating temperatures was 105℃, drying time was 104 min; Under these conditions, moisture content of dry extract was 2.80% on average, the transfer rate of polydatin was 92.55%, and the transfer rate of paeoniflorin was 94.77% on average, the composite score was 95.35 on average, RSD=0.42%. Conclusion: The condition optimized by using response surface methodology is stable and reasonable, which could guide industrial production and keep high transfer rate of effective component.
