A new chain-like cembranoid diterpene from leaves of Nicotiana tabacum
10.7501/j.issn.0253-2670.2015.14.003
- Author:
Qing-Xia ZHENG
1
Author Information
1. Zhengzhou Tobacco Research Institute of CNTC
- Publication Type:Journal Article
- Keywords:
Cembranoid diterpenes;
Chain-like diterpene;
Nicotiaditerpene A;
Nicotiana L.;
Nicotiana tabacum L.
- From:
Chinese Traditional and Herbal Drugs
2015;46(14):2040-2044
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the cembranoid diterpenes from the leaves of Nicotiana tabacum. Methods: The cembranoid diterpenes were isolated and purified by silica gel and preparative HPLC, and their structures were elucidated on the basis of their physicochemistry properties and spectral data. Results: Five cembranoid diterpenes were obtained from the ethanol extract of the leaves of N. tabacum and identified as (1S,2E,4R,6R,7E)-4,6,11-trihydroxy-1-isopropyl-4,8-dimethylpentadeca-2,7-dien-12-one (1), (1S,2E,4R,6R,7E,11E)-2,7,11-cembradiene-4,6-diol (2), (1S,2E,4S,6R,7E,11E)-2,7,11-cembradiene-4,6-diol (3), (1S,2E,4R,6R,7E, 11S)-2,7,12 (20)-cembratriene-4,6,11-triol (4), and (1S,2E,4S,6R,7E,11S)-2,7,12(20)-cembratriene-4,6,11-triol (5). Conclusion: Compound 1 is a new chain-like cembranoid diterpene named nicotiaditerpene A.
