Comparison on release and transdermal behavior in vitro between Dinggui Gel Paste and Dinggui Huoluo Rubber Patch
10.7501/j.issn.0253-2670.2015.15.008
- Author:
Li-Yang ZHU
1
Author Information
1. Sichuan Provincial Orthopedic Hospital
- Publication Type:Journal Article
- Keywords:
Dinggui Gel Paste;
Dinggui Huoluo Rubber Patch;
Notopterol;
Strat-M membrane;
Transdermal test
- From:
Chinese Traditional and Herbal Drugs
2015;46(15):2223-2227
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the release and transdermal behavior in vitro between Dinggui Huoluo Rubber Patch (DHRP) and Dinggui Gel Paste (DGP) which is the improved form. Methods: Microporous filter membrane or Strat-M membrane and advanced Franz diffusion cell were chosen in the release and transdermal experiment in vitro. The content of notopterol, the active component of the key herb Notopterygium incisum in the preparation, was quantitatively determined by HPLC method to determine the release rate, penetration quantity, and penetration rate of the two forms. Results: The penetration formula of DGP was Ln = 9.208 t-18.50, r = 0.948. The in vitro cumulative release rate, penetration quantity, and penetration rate were respectively 85.34%, 0.661 8 mg/g, and 65.67%. The penetration formula of DHRP was Ln = 4.285 t-6.704, r = 0.977. The in vitro cumulative release rate, penetration quantity, and penetration rate were respectively 67.87%, 0.181 6 mg/g, and 31.35%. Conclusion: The transdermal behavior of DGP is obviously better than that of DHRP while its quantity and the rate of penetration and release are all better than those of rubber patch. Meanwhile the gel paste is less sensitized and more convenient to use.
