Application advances on zebra-fish model in study on Chinese materia medica
10.7501/j.issn.0253-2670.2015.17.022
- Author:
Chong-Jun ZHAO
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Active ingredient screening;
Chinese materia medica;
Metabolism;
Toxicity;
zebra fish
- From:
Chinese Traditional and Herbal Drugs
2015;46(17):2635-2648
- CountryChina
- Language:Chinese
-
Abstract:
Zebra fish, as a model organism, has been widely used in genetics and developmental biology. In recent years, researches on the zebra fish have expanded and extended the field of Chinese materia medica (CMM) since it is a useful model of choice for in vivo pharmacology dynamic screening. Through zebra fish, we are able to fully detect and identify the substances of activity and/or toxicity of CMM with the advantage of real-time dynamic monitoring, thus achieving high-throughput screening. In this article, we outline the features of the zebra fish model and summarize its progress in screening toxicity and active substances of CMM as well as metabolic study in vivo.
