Intervention mechanisms of Chinese materia medica on inflammatory injury of renal tissue with chronic nephropathy
10.7501/j.issn.0253-2670.2015.19.022
- Author:
Wen-Jie LIANG
1
Author Information
1. Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
Chronic nephropathy;
Inflammatory injury;
Mechanisms;
Signal transduction paths
- From:
Chinese Traditional and Herbal Drugs
2015;46(19):2946-2953
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease is closely related to inflammation. Chinese materia medica (CMM) or their extracts can intervene in some signal transduction paths such as nuclear factor-kappa B (NF-κB) path, mitogen activated protein kinase (MAPK) path, Toll-like receptor 4 (TLR4) path, and regulate cytokines, adhesion molecules, transcription factors, acceptor molecules, and enzyme molecules to resist inflammatory injury of renal tissue from multiple target points. Because of the interaction, network, and magnification of inflammatory injury factors, the action of CMM shows the characteristics, such as multi-point, pleiotropy, overlap, and so on. The target points of CMM on inflammatory injury are explored and their molecular mechanism plays an important role in the prevention and control of chronic kidney disease and study on new drug.
