A new neoclerodane diterpenoid from Scutellaria barbata
10.7501/j.issn.0253-2670.2015.19.004
- Author:
Cai-Xia LIANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
Antitumor;
Neoclerodane diterpenoid;
Scutellaria barbata D. Don;
Scutellaria Linn;
Scutellone J
- From:
Chinese Traditional and Herbal Drugs
2015;46(19):2843-2845
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the whole plant of Scutellaria barbata. Methods: The constituents were isolated and purified by using various column chromatographic techniques including silica gel column chromatography, MCI, ODS, and Sephadex LH-20, the structures were identified by spectroscopic analyses including HR-ESI-MS, NMR, and 2D-NMR. Results: A new neoclerodane diterpenoid named scutelinquanine E was isolated from the whole plant of S. barbata, and its structrue was identified as (13R)-7β-hydroxy-8,13-epoxy-6α,11β-diacetoxy-ent-clerodan-3-en-15, 16-olide. Conclusion: Compound 1 is a new neoclerodane diterpenoid named as scutellone J.
