Research progress on natural products on new targets of type 2 diabetes
10.7501/j.issn.0253-2670.2015.21.026
- Author:
Jia-Yin YUE
1
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
AMP-activated protein kinase;
Dipeptidyl peptidase-IV;
Natural products;
New targets;
Peroxisome proliferators-activated receptor;
Protein tyrosine phosphatase 1B;
Type 2 diabetes
- From:
Chinese Traditional and Herbal Drugs
2015;46(21):3272-3278
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabete, caused by inadequate secretion of insulin and insulin resistance in tissues and organs, is also called non insulin dependent diabete. At present, over 90% diabetes is type 2 diabete which is seriously harmful to human health, however, the current clinical application of chemical synthetic medicines have different degrees of side effects. Therefore, the study of components with antidiabetic activity acting on different targets from the natural products with low toxicity has become a focus of current research. The new targets, such as PTP1B, DPP-IV, PPAR, and AMPK, were discovered in recent years. In this paper, active components in natural products on new targets for diabetes are reviewed, so as to provide the reference for the further research of diabetes.
