Protection of extract from pigeonpea leaves on myocardial ischemia reperfusion injury in rats
10.7501/j.issn.0253-2670.2015.22.016
- Author:
Lin SUN
1
Author Information
1. Shanxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Arrhythmia;
Infarct size;
Myocardial ischemia reperfusion injury;
Pigeonpea leaves;
Ventricular fibrillation
- From:
Chinese Traditional and Herbal Drugs
2015;46(22):3382-3385
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the protective effects of pigeonpea leaves on myocardial ischemia reperfusion injury in rats. Methods: A model of myocardial ischemia reperfusion was established by ligating the anterior descending coronary arteries. Rats were administrated with extract from pigeonpea leaves (125, 200, and 500 mg/kg) before ischemia, and the size of myocardial infarction, arrhythmia score, and morphological changes of cardiomyocytes were determined. Results: Compared with the model group, pigeonpea leaves could reduce arrhythmia severity and incidence (P<0.05 or 0.01) and the size of myocardial infarction (P<0.05). Pigeonpea leaves could ameliorate the pathological lesion. Conclusion: Pigeonpea leaves have the protective effects on myocardial ischemia reperfusion injury in rats.
