Preparation and characterization of salidroside phospholipid complex in Rhodiola crenulota
10.7501/j.issn.0253-2670.2015.22.008
- Author:
Hai-Ping XUE
1
Author Information
1. Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Characterization;
Complexing rate;
Orthogonal design;
Phospholipid complex;
Salidroside
- From:
Chinese Traditional and Herbal Drugs
2015;46(22):3333-3337
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare salidroside (SAD) phospholipid complex in Rhodiola crenulota and search for its optimum preparation and characterization. Methods: Taking the ratio of salidroside and phospholipid as index, the factors that might affect the combination percentage of SAD with PLC (SAD-PLC) were investigated, separately. At the same time, UV, FT-IR, and XRD microscope anaIysis techniques were used to analyze the structure of SAD phospholipid complex. Results: In the optimum preparation process of SAD-PLC, tetrahydrofuran was used as reaction solvent, the weight ratio of SAD to phospholipid was 1:4, and the total concentration of SAD and PLC in the reaction solvent was 10 mg/mL, the reaction temperature was 20℃. Conclusion: The reaction ratio, concentration of SAD, and reaction time have geater impact on the formation of phospholipid complex, and the reaction temperature also has some impact. Chemical changes do not occur in the formation process, but the phospholipid complex is different with the simple physical mixtures.
