Analysis on ideas and methods to identify target components group of Chinese materia medica preparation
10.7501/j.issn.0253-2670.2015.23.001
- Author:
Deng-Jie WANG
1
Author Information
1. College of Pharmacy, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Integration effect correlation analysis;
Knock-in/knock-out;
Pharmacokinetics;
Serum medicinal chemistry;
Serum pharmacology;
Spectral-efficiency relationships;
Target components group;
Virtual screening
- From:
Chinese Traditional and Herbal Drugs
2015;46(23):3447-3454
- CountryChina
- Language:Chinese
-
Abstract:
The preparation of Chinese materia medica (CMM) possesses the characteristic of holistic function involving multi-component, multi-target, and multi-link. This characters make it difficult to optimize the preparation process and construct the quality standards of CMM. Thus process building and quality evaluation system based on correctly identifying the components that closely related to the efficacy is a key scientific issue in the preparation process design and quality control of CMM. In this paper, a more comprehensive analysis on the feasibility of different research methods was carried out, including the spectral-efficiency relationships, pharmacokinetics, serum medicinal chemistry and serum pharmacology of drugs, the effect of integration effect correlation analysis, virtual screening, and comparative analysis of knock-in/knock-out. The purpose of this article is to provide the reference for identifying the bioactive marker group which is used for the CMM preparation process and quality evaluation.
