System evaluation on efficacy and safety of Kushen Gel for treatment of bacterial and trichomonas vaginitis
10.7501/j.issn.0253-2670.2015.24.028
- Author:
Lin LAN
1
Author Information
1. Guiyang Maternity and Child Health Hospital
- Publication Type:Journal Article
- Keywords:
Efficacy;
Kushen Gel;
Meta-analysis;
Metronidazole;
Safety
- From:
Chinese Traditional and Herbal Drugs
2015;46(24):3779-3782
- CountryChina
- Language:Chinese
-
Abstract:
Related randomly controlled trials about Kushen Gel and Metronidazole in recent 10 years were collected by various kinds of database according to strict inclusion and exclusion criteria. Valid data were extracted to conduct Meta-analysis by RevMan5.0. To evaluate the efficacy and safety of Kushen Gel and Metronidazole for bacterial and trichomonas vaginitis. A total of 63 articles were retrieved, but only four of them were finally included. Meta-analysis showed that the effective proportion of Kushen Gel was significantly higher than that of Metronidazole [RR=1.13, 95% CI (1.06 and 1.20), P < 0.01]. The incidence of adverse effects was significantly lower in Kushen group compared to the Metronidazole group [RR=0.29, 95% CI (0.15 and 0.56), P < 0.01]. Kushen Gel can improve symptoms of vaginitis more effectively than Metronidazole and tend to have lower incidence of adverse effects.
