Preparation of emulsion-hydrogel transdermal patch of essential oil from Artemisiae Argyi Folium and its transdermal characteristics
10.7501/j.issn.0253-2670.2015.24.008
- Author:
Yue-Bin GE
1
Author Information
1. School of Pharmacy, South-Central University for Nationalities
- Publication Type:Journal Article
- Keywords:
180° peeling strength;
Borneol;
Camphor;
Cohesion;
Dihydroxyaluminium aminoacetate;
EDTA;
Essential oil from Artemisia Argyi Folium;
Eucalyptol;
Hold force;
Hydrogel transdermal patch;
Initial adhesive force;
Orthogonal design;
Permeability;
Permeating rate;
Sodium polyacrylate
- From:
Chinese Traditional and Herbal Drugs
2015;46(24):3661-3665
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize formulations of emulsion-hydrogel transdermal patch of essential oil from Artemisia Argyi Folium, and to evaluate its transdermal characteristics in vitro. Methods: The formulations were optimized by orthogonal experiment with four factors including hydrogel patch carrier (sodium polyacrylate NP-700), crosslinking agent (dihydroxyaluminium aminoacetate), crosslinking modifier (EDTA), and moisturizing agent (glycerol). Initial adhesive force, hold force, 180° peeling strength, cohesion, and permeability were measured. In addition, the contents of eucalyptol, camphor, and borneol in hydrogel transdermal patch were analyzed by GC. Results: The impacting factors which affected the patch shaping were in the order of glycerol > dihydroxyaluminium aminoacetate > EDTA > sodium polyacrylate NP-700. The optimized formulation was as following: 30% glycerol, 5% NP-700, 0.3% dihydroxyaluminium aminoacetate, and 0.03% EDTA. The permeation rates of eucalyptol, camphor, and borneol were 85.216, 4.442, and 3.941 μg/(cm2∙h), respectively. Conclusion: Emulsion-hydrogel transdermal patch of essential oil from Artemisia Argyi Folium has a better quality and a transdermal property of zero-order release process.
