Effects of Shufengjiedu Capsule on model of viral myocarditis in mice
10.7501/j.issn.0253-2670.2016.01.017
- Author:
Ya-Ping ZHANG
1
Author Information
1. Department of Emergency, Zhongshan Hospital, Fudan University
- Publication Type:Journal Article
- Keywords:
Antivirus;
Coxsackie virus B3;
SAA;
Shufengjiedu Capsule;
TNF-α;
Viral myocarditis
- From:
Chinese Traditional and Herbal Drugs
2016;47(1):110-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Shufengjiedu Capsule on the modality of myocardial tissue and levels of serum TNF-α and SAA in mice with viral myocarditis. Methods: BALB/C mice were randomly divided into normal control group, virus group, Shufengjiedu Capsule 0.1, 0.2, 0.5 g/kg/d groups, and ribavirin 0.1 g/kg/d group. The mouse model of viral myocarditis was established by ip injection of CVB3, and after 2 h of modeling, the animals were continuously admistered for 7 d. Half of the mice were killed on days 4 and 8, the myocardium tissue was HE stained to observe the pathological changes and blood samples were taken for measurement of serum TNF-α and SAA contents. Results: Compared with the control group, the pathological changes of myocardium were significantly decreased in high-dose Shufengjiedu Capsule group, and the serum TNF-α and SAA contents were significantly decreased (P < 0.05). Conclusion: Shufengjiedu Capsule has antiviral effect and could alleviate the inflammation on mice with viral myocarditis.
