Preparation of glycyrrhetinic acid niosomes and optimization of its prescription process
10.7501/j.issn.0253-2670.2016.02.011
- Author:
Xi-Xiang LI
1
Author Information
1. Gansu Province Hospital of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Central composite design-response surface methodology;
Glycyrrhetinic acid;
Niosomes;
Nonionic surfactants;
Thin film dispersion-ultrasonic method
- From:
Chinese Traditional and Herbal Drugs
2016;47(2):240-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective: With nonionic surfactants as the carrier material to prepare glycyrrhetinic acid (GC) niosomes (NI) and to evaluate the quality. Methods: The thin film dispersion-ultrasound method was used for establishing the preparation process of GC - NI, reverse dialysis method and ultraviolet spectrophotometer method were used to determine the encapsulation efficiency (EE), the prescription and preparation process were optimized through single factor and central composite design-response surface methodology (CCD-RSM), and the properties of morphology, particle size, Zeta potential, and EE in optimized NI were investigated. Results: The optimum prescription process as Span 80-cholesterol was 2:1, hydration temperature was 70℃, hydration time was 51 min, ultrasonic time was 60 min, its forecast EE was 80.66%, bias between the observed and predicted values was 4.95%, and regression coefficient of binomial fitting complex model was as high as 0.989 9. Conclusion: CCD-RSM is used to optimize the preparation, which has the stable, feasible, high precision, and good predictability advantage.
