Optimization of extraction process for Xinshenning Tablets by Plackett- Burnman, Box-Behnken, and response surface methodology
10.7501/j.issn.0253-2670.2016.03.013
- Author:
Jia SONG
1
Author Information
1. Chengde Medical College
- Publication Type:Journal Article
- Keywords:
Box-Behnken design;
Extraction process;
Extraction rate;
Geniposide;
Plackett-Burnman design;
Response surface methodology;
Spinosin;
Xinshenning Tablets
- From:
Chinese Traditional and Herbal Drugs
2016;47(3):430-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the extraction process for Xinshenning Tablets. Methods: The extracting condition was optimized by Plackett-Burnman, Box-Behnken, and response surface methodology with the extraction rate, geniposide, and spinosin as indexes. Results: The optimal extracting condition was extracting 3 times with 7.5 fold 70% alcohol, 1.5 h for each time. Conclusion: The optimized process condition is simple and feasible. It can be used in the production.
