Structural modification and biological evaluation of monomeric compounds from Aralia elata
10.7501/j.issn.0253-2670.2016.04.006
- Author:
Hai-Bo WU
1
Author Information
1. Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology
- Publication Type:Journal Article
- Keywords:
Aralia elata (Miq.) Seem.;
H9c2 cells;
Myocardial protection activity;
Oleanolic acid-3-O-β-D-glucuronide;
Structural modification
- From:
Chinese Traditional and Herbal Drugs
2016;47(4):559-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To modify the structure of natural monomeric compound based on oleanolic acid-3-O-β-D-glucuronide from medicinal plant Aralia elata and to evaluate the myocardial protection activity of the derivatives. Methods: Taking oleanolic acid or ursolic acid as material, the target compounds were prepared by five steps of reactions and evaluated for myocardial protection effects by H9c2 cells in vitro. Results: Ten derivatives F1-F10 were synthesized. The structures of the target compounds were identified by spectrum. Pharmacological results showed that all of the compounds had the different levels potency of myocardial protection effects in cells. In particular, compounds F3 showed the significant myocardial protection activity compared to lead compound. Conclusion: The new compounds F1-F10 which show the potential of biological activity in myocardial protection, have not been reported in any literature and deserved further research.
