Study on matrix proportion of hydrophilic SIS hot melt pressure sensitive adhesive suit modified by RLPO
10.7501/j.issn.0253-2670.2016.05.010
- Author:
Xu ZHAO
1
Author Information
1. Henan Province Hospital of TCM
- Publication Type:Journal Article
- Keywords:
Antioxidant 1010;
C5 petroleum resin hydrogenate;
Dibutyl phthalate;
Hot melt pressure sensitive adhesive;
Hydrophilic;
Lanoline styrene-isoprene-styrene triblock copolymer;
Liquid paraffin;
Patch;
Polyethylene glycol 400;
Release rate;
RLPO;
Transdermal delivery system
- From:
Chinese Traditional and Herbal Drugs
2016;47(5):748-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the matrix proportion of SIS hot melt pressure sensitive adhesive suit for hydrophilic material releasing. Methods: By orthogonal test method, taking adhesiveness and hydrophilic drug release rate as factors, and C5 petroleum resin hydrogenate, lanoline styrene-isoprene-styrene (SIS) triblock copolymer, ethyl acrylate-methyl methacrylate-trimethylamino (RLPO), liquid paraffin, dibutyl phthalate (DOP), polyethylene glycol (PEG) 400, and Antioxidant 1010 as materials, the matrix proportion was optimized. Results: The optimized formulation was as follows: SIS-C5 petroleum resin hydrogenate-SIS-RLPO-DOP-PEG 400-Antioxidant 1010 was 3:4:6:6:5:1:0.1. The adhesiveness was proper and shows more release rate for hydrophilic material. Conclusion: The SIS hot melt pressure sensitive adhesive shows good property and is suitable to prepare transdermal patch.
