Advances in studies on ovarian cancer treated by triptolide
10.7501/j.issn.0253-2670.2016.06.029
- Author:
Qin-Hang WU
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cancer cell metastasis;
Cell apoptosis;
Cell cycle;
Mechanism of action;
Ovarian cancer;
Triptolide
- From:
Chinese Traditional and Herbal Drugs
2016;47(6):1049-1052
- CountryChina
- Language:Chinese
-
Abstract:
Triptolide is an epoxidated diterpene lactone compound separated from Tripterygium wilfordii. It has been reported that triptolide inhibits the growth of ovarian cancer cells in vitro and suppresses tumor growth in vivo. Triptolide could also sensitize ovarian cancer cells to cisplatin. Having combined the latest literatures on the effects of triptolide on ovarian cancer domestic and abroad, this article reviews the recent research advances in the anti-ovarian cancer activity of triptolide and its mechanisms which include inducing apoptosis of ovarian cancer cells, interfering in the cell cycle, and suppressing cell metastasis.
