Mechanisms of Chinese materia medica multi-target to reverse MDR of leukemia
10.7501/j.issn.0253-2670.2016.07.028
- Author:
Ye-Ye SHI
1
Author Information
1. College of Pharmacy, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
Leukemia;
Malignant tumors;
Multidrug resistance mechanisms;
Reversal agents
- From:
Chinese Traditional and Herbal Drugs
2016;47(7):1230-1235
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia is a common malignant tumor in blood system, and it is one of the 10 high incidence malignant tumors in China. The main reason related to the failure of chemotherapy in leukemia is multidrug resistance (MDR). Chemical reversal agents often have the side effects and the mechanisms of chemical reversal agents are single, which restricts its clinical application. With efficiency, low-level toxicity, and multi-target points, Chinese materia medica shows its unique advantages in reversing MDR of leukemia. This paper summarizes the MDR mechanisms of leukemia and reversal agents in Chinese medicine in order to find more Chinese medicine to reverse leukemia.
