Chemical constituents from Spiraea pubescens

Author: Hui-Li YAO ¹
Author Information

1. College of Pharmacy, Qingdao University
Publication Type:Journal Article
Keywords: (+)-lyoniresinol; (6S,9R)-6-; (7R,8R)-4,7,9,9'-tetrahydroxy-3,3'-diethoxy-8-O-4'-neolignan; hydroxy-3-one-α-ionol-9-O-β-D-glucopyranoside; Lignans; Spiraea pubescens
From: Chinese Traditional and Herbal Drugs 2016;47(9):1486-1491
CountryChina
Language:Chinese
Abstract: Objective: To investigate the chemical constituents from the ethanol extract of Spiraea pubescens. Methods: The compounds were isolated and purified by chromatography on silica gel, ODS, and preparative HPLC. Their structures were elucidated on the basis of chemical and spectroscopic methods, including MS, 1D, and 2D NMR spectral techniques. Results : Fourteen compounds were isolated and identified as β-sitosterol (1), tricosyl alcohol (2), stigmast-4-en-3-one (3), pentacosyl alcohol (4), stigmastanol (5), (+)-cyclo-olivil (6), (+)-africannal (7), (+)-lyoniresinol (8), 5-methoxy-(+)-isolariciresinol (9), (+)-isolariciresinol (10), (7R,8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan (11), (6S,9R)-6-hydroxy-3-one-α-ionol-9-O-β-D-glucopyranoside (12), (+)-lyoniresinol 9-O-β-D-xylopyranoside (13), and (-)-lyoniresinol 9-O-β-D-xylopyranoside (14). Conclusion: Compounds 2-5 and 7-14 are isolated from the plants of Spiraea L. for the first time, and compounds 1 and 6 are obtained from this plant for the first time.