Cerebellar Degeneration Associated with Sjogren's Syndrome.

Author: Mi Jung KIM ¹ ; Myoung Chong LEE ; Jae Hong LEE ; Sun Ju CHUNG
Author Information

1. Department of Health Screening and Promotion Center, Asan Medical Center, Seoul, Korea.
Publication Type:Case Report
Keywords: Sjogren's syndrome; cerebellar degeneration; ataxia; cognitive impairment
MeSH: Ataxia; Atrophy; Brain; Cerebellar Ataxia; Cerebellar Diseases; Cerebellum; Glucose; Humans; Magnetic Resonance Imaging; Neurologic Manifestations; Polyneuropathies; Positron-Emission Tomography; Sjogren's Syndrome
From:Journal of Clinical Neurology 2012;8(2):155-159
CountryRepublic of Korea
Language:English
Abstract: BACKGROUND: Neurologic manifestations of primary Sjogren's syndrome (PSS) have been reported to vary from sensory polyneuropathy to encephalopathy or psychiatric problems. However, marked cerebellar degeneration associated with PSS has rarely been reported. CASE REPORT: We describe a patient with Sjogren's syndrome who exhibited rapidly progressive cerebellar ataxia, nystagmus, cognitive decline, and psychiatric problems. Brain magnetic resonance imaging revealed marked atrophy of the cerebellum, and 18F-fluorodeoxyglucose positron-emission tomography demonstrated glucose hypometabolism of the cerebellum. CONCLUSIONS: Our PSS patient exhibited a progressive course of cerebellar syndrome, as evidenced by cerebellar atrophy on serial brain images.