Effect of administration temperature on efficacy of Gegen Qinlian Decoction on DSS-induced ulcerative colitis in rats
10.7501/j.issn.0253-2670.2016.16.021
- Author:
Guan-Zhen GAO
1
Author Information
1. College of Food and Biological Engineering, Zhejiang Industrial and Commercial University
- Publication Type:Journal Article
- Keywords:
Administration temperature;
Dextran sulfate sodium;
Disease activity index;
Gegen Qinlian Decoction;
GSH-Px;
Malondialdehyde;
Myeloperoxidase;
Superoxide dismutase;
Tumor necrosis factor;
Ulcerative colitis
- From:
Chinese Traditional and Herbal Drugs
2016;47(16):2897-2901
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of the administration temperature of GQD on the efficacy to ulcerative colitis (UC) of rats. Methods: The GQD was given to dextran sulfate sodium (DSS)-induced UC rats at different temperature (10℃/42℃) for 7 d. The disease activity index (DAI), histopathological score of colon, superoxide dismutase (SOD), malondialdehyde (MDA), GHS-Px, myeloperoxidase (MPO) of serum and colon tissue, and the tumor necrosis factor (TNF-α) of serum were measured and observed. Results: Compared with the control group, the UC relative symptom and index changes of rats in the model group appeared obviously. GQD showed the significant therapeutic effects in both 10℃ and 42℃ groups. The lower temperature administration achieved significantly better results than the higher one on the histopathological score, colon wall thickness, and biochemical indices. Conclusion: The cold GQD shows higher efficacy than the hot GQD when treating UC, which may be attributed to the immune response of intestinal mucosal mast cells to temperature-induced stress.
