Chemical constituents from Spiraea salicifolia
10.7501/j.issn.0253-2670.2016.16.004
- Author:
Shi-Da YAN
1
Author Information
1. College of Pharmacy, Qingdao University
- Publication Type:Journal Article
- Keywords:
7S,8R-3,5-dimethoxy-4',7-epoxy-8,5'-neolignan-3',4,9,9'-tetraol;
Lignan;
Salicifoneoliganol;
Spiraea salicifolia L.;
Triterpene
- From:
Chinese Traditional and Herbal Drugs
2016;47(16):2806-2811
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents from the ethanol extract of Spiraea salicifolia. Methods: The compounds were isolated and purified by chromatography on silica gel, ODS, and preparative HPLC methods. Their structures were elucidated on the basis of chemical and spectral data. Results: Twelve compounds were isolated and identified as 7S,8R-3,5- dimethoxy-4',7-epoxy-8,5'-neolignan-3',4,9,9'-tetraol (1, salicifoneoliganol), 3β-acetylursolic acid methyl ester (2), 3β-acetyloleanolic acid methyl ester (3), lupeol (4), β-amyrin (5), (7R,8S)-5-methoxydiyhdrodehydroconiferyl alcohol (6), 8-hydroxy-7'-epipinoresinol (7), 8-hydroxypinoresinol (8), fraxiresinol (9), (+)-africannal (10), (+)-lyoniresinol (11), and 5-methoxy-(+)-isolariciresinol (12). Conclusion: Compound 1 is a new lignan named salicifoneoliganol. Compounds 6 and 7 are isolated from the plants of Spiraea L. for the first time, and compounds 4, 5, and 8-12 are firstly obtained from this plant. Compounds 2 and 3 are artifacts of isolation from ursolic acid and loleanolic acid.
