A new 2-arylbenzofuran from twigs of Cassia alata and its cytotoxicity
10.7501/j.issn.0253-2670.2016.17.003
- Author:
Hang-Ying MA
1
Author Information
1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University
- Publication Type:Journal Article
- Keywords:
2-(2'-methoxy-4'- hydroxy-aryl)-3-methy-6-hydroxybenzofuran;
7-methoxy-2-(4-methoxyphenyl)-3,5-dimethylbenzofuran;
Cassia alata L.;
Cytotoxic activity;
Dai medicine;
Moracin N;
Moracin P
- From:
Chinese Traditional and Herbal Drugs
2016;47(17):2975-2978
- CountryChina
- Language:Chinese
-
Abstract:
Objective: For the purpose of finding new bioactive agents from ethnic medicines, the chemical study on Dai Medicine Cassia alata was carried out. Methods: The chemical constituents from the twigs of C. alata were isolated by column chromatographic methods of silica gel, MCI-Gel resin, Sephadex LH-20, and HPLC. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The cytotoxicity of this compound for NB-4, A-549, SHSY5Y, PC-3, and MCF-7 cells line was also evaluated by using the MTT method. Results: Four 2-arylbenzofuran compounds were isolated from this plant and identified as 7- methoxy-2-(4-methoxyphenyl)-3,5-dimethylbenzofuran (1), moracin N (2), 2-(2'-methoxy-4'-hydroxy-aryl)-3-methy-6-hydroxybenzofuran (3), and moracin P (4). Conclusion: Compound 1 is a new compound named as 7-methoxy-2-(4-methoxyphenyl)-3,5-dimethylbenzofuran. Compound 1 also displays the high cytotoxicity to tested cancer cell-line.
